| October 17, 2021 | ||
| Nordsjælland | 13:00 | Midtjylland |
| OB | 14:00 | Randers |
| Brøndby | 16:00 | Vejle |
| SønderjyskE | 18:00 | FC Copenhagen |
| October 18, 2021 | ||
| AGF | 19:00 | AaB |
| October 22, 2021 | ||
| Vejle | 19:00 | Nordsjælland |
| October 24, 2021 | ||
| Brøndby | 14:00 | FC Copenhagen |
| Silkeborg | 14:00 | OB |
| Randers | 16:00 | AGF |
| Midtjylland | 18:00 | SønderjyskE |
| October 25, 2021 | ||
| AaB | 19:00 | Viborg |
| October 31, 2021 | ||
| Nordsjælland | 16:00 | AaB |
| Randers | 16:00 | Midtjylland |
| FC Copenhagen | 18:00 | Vejle |
| Viborg | 20:00 | Brøndby |
| SønderjyskE | 22:00 | Silkeborg |
| November 1, 2021 | ||
| OB | 21:00 | AGF |
| November 5, 2021 | ||
| Viborg | 21:00 | Nordsjælland |
