| January 23, 2022 | ||
| Hertha Berlin | 1 - 4 | Bayern Munich |
| RB Leipzig | 2 - 0 | Wolfsburg |
| January 22, 2022 | ||
| VFL Bochum | 2 - 2 | FC Cologne |
| Greuther Fürth | 2 - 1 | Mainz |
| TSG 1899 Hoffenheim | 2 - 3 | Borussia Dortmund |
| SC Freiburg | 2 - 0 | Stuttgart |
| Borussia Mönchengladbach | 1 - 2 | Union Berlin |
| Bayer 04 Leverkusen | 5 - 1 | Augsburg 1907 |
| January 21, 2022 | ||
| Eintracht Frankfurt | 0 - 2 | Arminia Bielefeld |
| January 16, 2022 | ||
| Arminia Bielefeld | 2 - 2 | Greuther Fürth |
| Augsburg 1907 | 1 - 1 | Eintracht Frankfurt |
| January 15, 2022 | ||
| Borussia Mönchengladbach | 1 - 2 | Bayer 04 Leverkusen |
| FC Cologne | 0 - 4 | Bayern Munich |
| Mainz | 1 - 0 | VFL Bochum |
| Stuttgart | 0 - 2 | RB Leipzig |
| Union Berlin | 2 - 1 | TSG 1899 Hoffenheim |
| Wolfsburg | 0 - 0 | Hertha Berlin |
| January 14, 2022 | ||
| Borussia Dortmund | 5 - 1 | SC Freiburg |
| January 9, 2022 | ||
| VFL Bochum | 1 - 0 | Wolfsburg |
| Hertha Berlin | 1 - 3 | FC Cologne |
