| March 7, 2021 | ||
| Arminia Bielefeld | 0 - 0 | Union Berlin |
| 1. FC Köln | 1 - 1 | Werder Bremen |
| March 6, 2021 | ||
| Bayern Munich | 4 - 2 | Borussia Dortmund |
| Hertha BSC | 2 - 1 | Augsburg 1907 |
| Eintracht Frankfurt | 1 - 1 | Stuttgart |
| SC Freiburg | 0 - 3 | RB Leipzig |
| TSG 1899 Hoffenheim | 2 - 1 | Wolfsburg |
| Borussia Mönchengladbach | 0 - 1 | Bayer 04 Leverkusen |
| March 5, 2021 | ||
| Schalke 04 | 0 - 0 | 1. FSV Mainz 05 |
| February 28, 2021 | ||
| Bayer 04 Leverkusen | 1 - 2 | SC Freiburg |
| 1. FSV Mainz 05 | 0 - 1 | Augsburg 1907 |
| Union Berlin | 1 - 1 | TSG 1899 Hoffenheim |
| February 27, 2021 | ||
| RB Leipzig | 3 - 2 | Borussia Mönchengladbach |
| Stuttgart | 5 - 1 | Schalke 04 |
| Wolfsburg | 2 - 0 | Hertha BSC |
| Borussia Dortmund | 3 - 0 | Arminia Bielefeld |
| Bayern Munich | 5 - 1 | 1. FC Köln |
| February 26, 2021 | ||
| Werder Bremen | 2 - 1 | Eintracht Frankfurt |
