| October 2, 2022 | ||
| Schalke 04 | 2 - 3 | Augsburg 1907 |
| Hertha Berlin | 1 - 1 | TSG 1899 Hoffenheim |
| October 1, 2022 | ||
| Werder Bremen | 5 - 1 | Borussia Mönchengladbach |
| Wolfsburg | 3 - 2 | Stuttgart |
| Eintracht Frankfurt | 2 - 0 | Union Berlin |
| FC Cologne | 3 - 2 | Borussia Dortmund |
| SC Freiburg | 2 - 1 | Mainz |
| RB Leipzig | 4 - 0 | VFL Bochum |
| September 30, 2022 | ||
| Bayern Munich | 4 - 0 | Bayer 04 Leverkusen |
| September 18, 2022 | ||
| TSG 1899 Hoffenheim | 0 - 0 | SC Freiburg |
| VFL Bochum | 1 - 1 | FC Cologne |
| Union Berlin | 2 - 0 | Wolfsburg |
| September 17, 2022 | ||
| Borussia Mönchengladbach | 3 - 0 | RB Leipzig |
| Bayer 04 Leverkusen | 1 - 1 | Werder Bremen |
| Augsburg 1907 | 1 - 0 | Bayern Munich |
| Stuttgart | 1 - 3 | Eintracht Frankfurt |
| Borussia Dortmund | 1 - 0 | Schalke 04 |
| September 16, 2022 | ||
| Mainz | 1 - 1 | Hertha Berlin |
| September 11, 2022 | ||
| SC Freiburg | 0 - 0 | Borussia Mönchengladbach |
| FC Cologne | 0 - 1 | Union Berlin |
