| September 19, 2021 | ||
| Wolfsburg | 1 - 1 | Eintracht Frankfurt |
| Borussia Dortmund | 4 - 2 | Union Berlin |
| Stuttgart | 1 - 3 | Bayer 04 Leverkusen |
| September 18, 2021 | ||
| FC Cologne | 1 - 1 | RB Leipzig |
| Arminia Bielefeld | 0 - 0 | TSG 1899 Hoffenheim |
| Augsburg 1907 | 1 - 0 | Borussia Mönchengladbach |
| Mainz | 0 - 0 | SC Freiburg |
| Bayern Munich | 7 - 0 | VFL Bochum |
| September 17, 2021 | ||
| Hertha Berlin | 2 - 1 | Greuther Fürth |
| September 12, 2021 | ||
| Borussia Mönchengladbach | 3 - 1 | Arminia Bielefeld |
| VFL Bochum | 1 - 3 | Hertha Berlin |
| Eintracht Frankfurt | 1 - 1 | Stuttgart |
| September 11, 2021 | ||
| RB Leipzig | 1 - 4 | Bayern Munich |
| Greuther Fürth | 0 - 2 | Wolfsburg |
| TSG 1899 Hoffenheim | 0 - 2 | Mainz |
| SC Freiburg | 1 - 1 | FC Cologne |
| Union Berlin | 0 - 0 | Augsburg 1907 |
| Bayer 04 Leverkusen | 3 - 4 | Borussia Dortmund |
| August 29, 2021 | ||
| Wolfsburg | 1 - 0 | RB Leipzig |
| Union Berlin | 2 - 1 | Borussia Mönchengladbach |
