| March 10, 2021 | ||
| Olympique de Marseille | 20:00 | Stade Rennais FC |
| March 12, 2021 | ||
| Stade de Reims | 22:00 | Olympique Lyonnais |
| March 13, 2021 | ||
| Angers SCO | 14:00 | Saint-Etienne |
| Olympique de Marseille | 18:00 | Brest |
| March 14, 2021 | ||
| Nîmes | 14:00 | Montpellier Hérault SC |
| Dijon | 16:00 | Girondins de Bordeaux |
| Lens | 16:00 | Metz |
| Lorient | 16:00 | OGC Nice |
| Stade Rennais FC | 16:00 | Strasbourg |
| Monaco | 18:05 | LOSC Lille Métropole |
| Paris Saint-Germain | 22:00 | Nantes |
| March 19, 2021 | ||
| OGC Nice | 22:00 | Olympique de Marseille |
| March 20, 2021 | ||
| Metz | 14:00 | Stade Rennais FC |
| LOSC Lille Métropole | 18:00 | Nîmes |
