| October 2, 2022 | ||
| Monaco | 17:05 | Nantes |
| Lens | 20:45 | Lyon |
| October 7, 2022 | ||
| Lyon | 21:00 | Toulouse |
| October 8, 2022 | ||
| Marseille | 17:00 | Ajaccio |
| Stade de Reims | 21:00 | Paris Saint-Germain |
| October 9, 2022 | ||
| Montpellier Hérault SC | 13:00 | Monaco |
| Angers | 15:00 | Strasbourg |
| Clermont | 15:00 | Auxerre |
| OGC Nice | 15:00 | ESTAC |
| Brest | 15:00 | Lorient |
| Stade Rennais FC | 17:05 | Nantes |
| LOSC Lille Métropole | 20:45 | Lens |
| October 14, 2022 | ||
| Strasbourg | 21:00 | LOSC Lille Métropole |
| October 15, 2022 | ||
| Lorient | 17:00 | Stade de Reims |
| Lens | 21:00 | Montpellier Hérault SC |
