| August 6, 2021 | ||
| Monaco | 21:00 | Nantes |
| August 7, 2021 | ||
| Lyon | 17:00 | Brest |
| ESTAC | 21:00 | Paris Saint-Germain |
| August 8, 2021 | ||
| Stade Rennais FC | 13:00 | Lens |
| Girondins de Bordeaux | 15:00 | Clermont |
| OGC Nice | 15:00 | Stade de Reims |
| Saint-Etienne | 15:00 | Lorient |
| Strasbourg | 15:00 | Angers |
| Metz | 17:00 | LOSC Lille Métropole |
| Montpellier Hérault SC | 20:45 | Marseille |
| August 15, 2021 | ||
| Marseille | 02:00 | Girondins de Bordeaux |
| Paris Saint-Germain | 02:00 | Strasbourg |
| Lens | 02:00 | Saint-Etienne |
| Lorient | 02:00 | Monaco |
| LOSC Lille Métropole | 02:00 | OGC Nice |
| Angers | 02:00 | Lyon |
| Brest | 15:00 | Stade Rennais FC |
| Clermont | 15:00 | ESTAC |
| Nantes | 15:00 | Metz |
| Stade de Reims | 15:00 | Montpellier Hérault SC |
