| November 21, 2021 | ||
| Lyon | 21:45 | Marseille |
| February 4, 2022 | ||
| Marseille | 22:00 | Angers |
| February 5, 2022 | ||
| Saint-Etienne | 18:00 | Montpellier Hérault SC |
| Monaco | 22:00 | Lyon |
| February 6, 2022 | ||
| Lorient | 14:00 | Lens |
| OGC Nice | 16:00 | Clermont |
| Stade de Reims | 16:00 | Girondins de Bordeaux |
| Strasbourg | 16:00 | Nantes |
| ESTAC | 16:00 | Metz |
| Stade Rennais FC | 18:00 | Brest |
| LOSC Lille Métropole | 21:45 | Paris Saint-Germain |
