| October 16, 2021 | ||
| Clermont | 17:00 | LOSC Lille Métropole |
| Lyon | 21:00 | Monaco |
| October 17, 2021 | ||
| ESTAC | 13:00 | OGC Nice |
| Girondins de Bordeaux | 15:00 | Nantes |
| Brest | 15:00 | Stade de Reims |
| Metz | 15:00 | Stade Rennais FC |
| Strasbourg | 15:00 | Saint-Etienne |
| Montpellier Hérault SC | 17:00 | Lens |
| Marseille | 20:45 | Lorient |
| October 22, 2021 | ||
| Saint-Etienne | 21:00 | Angers |
| October 23, 2021 | ||
| Nantes | 17:00 | Clermont |
| LOSC Lille Métropole | 21:00 | Brest |
| October 24, 2021 | ||
| OGC Nice | 13:00 | Lyon |
| Lens | 15:00 | Metz |
| Lorient | 15:00 | Girondins de Bordeaux |
| Stade de Reims | 15:00 | ESTAC |
| Stade Rennais FC | 15:00 | Strasbourg |
| Monaco | 17:00 | Montpellier Hérault SC |
| Marseille | 20:45 | Paris Saint-Germain |
| October 27, 2021 | ||
| OGC Nice | 21:00 | Marseille |
