| October 3, 2021 | ||
| Atalanta | 2 - 3 | AC Milan |
| Roma | 2 - 0 | Empoli |
| Fiorentina | 1 - 2 | SSC Napoli |
| Sampdoria | 3 - 3 | Udinese |
| Verona | 4 - 0 | Spezia |
| Bologna | 3 - 0 | Lazio |
| October 2, 2021 | ||
| Sassuolo | 1 - 2 | Inter Milan |
| Torino | 0 - 1 | Juventus |
| Salernitana | 1 - 0 | Genoa |
| October 1, 2021 | ||
| Cagliari | 1 - 1 | Venezia |
| September 27, 2021 | ||
| Venezia | 1 - 1 | Torino |
| September 26, 2021 | ||
| SSC Napoli | 2 - 0 | Cagliari |
| Lazio | 3 - 2 | Roma |
| Empoli | 4 - 2 | Bologna |
| Udinese | 0 - 1 | Fiorentina |
| Sassuolo | 1 - 0 | Salernitana |
| Juventus | 3 - 2 | Sampdoria |
| September 25, 2021 | ||
| Genoa | 3 - 3 | Verona |
| Inter Milan | 2 - 2 | Atalanta |
| Spezia | 1 - 2 | AC Milan |
