| January 23, 2022 | ||
| AC Milan | 0 - 0 | Juventus |
| Empoli | 2 - 4 | Roma |
| Torino | 1 - 1 | Sassuolo |
| Spezia | 1 - 0 | Sampdoria |
| SSC Napoli | 4 - 1 | Salernitana |
| Cagliari | 1 - 1 | Fiorentina |
| January 22, 2022 | ||
| Lazio | 0 - 0 | Atalanta |
| Inter Milan | 2 - 1 | Venezia |
| Genoa | 0 - 0 | Udinese |
| January 21, 2022 | ||
| Verona | 2 - 1 | Bologna |
| January 17, 2022 | ||
| Fiorentina | 6 - 0 | Genoa |
| Bologna | 0 - 2 | SSC Napoli |
| AC Milan | 1 - 2 | Spezia |
| January 16, 2022 | ||
| Atalanta | 0 - 0 | Inter Milan |
| Roma | 1 - 0 | Cagliari |
| Venezia | 1 - 1 | Empoli |
| Sassuolo | 2 - 4 | Verona |
| January 15, 2022 | ||
| Juventus | 2 - 0 | Udinese |
| Salernitana | 0 - 3 | Lazio |
| Sampdoria | 1 - 2 | Torino |
