| November 29, 2020 | ||
| PSV Eindhoven | 1 - 0 | Sparta Rotterdam |
| Heracles Almelo | 1 - 2 | AZ |
| Feyenoord | 1 - 1 | Utrecht |
| Groningen | 1 - 0 | Willem II |
| Vitesse | 2 - 0 | Fortuna Sittard |
| November 28, 2020 | ||
| VVV-Venlo | 2 - 2 | PEC Zwolle |
| ADO Den Haag | 1 - 1 | Heerenveen |
| Emmen | 0 - 5 | Ajax |
| November 27, 2020 | ||
| Twente | 0 - 2 | RKC Waalwijk |
| November 22, 2020 | ||
| AZ | 1 - 0 | Emmen |
| RKC Waalwijk | 1 - 1 | Heerenveen |
| Twente | 1 - 1 | PSV Eindhoven |
| Fortuna Sittard | 1 - 3 | Feyenoord |
| Sparta Rotterdam | 6 - 0 | ADO Den Haag |
| Ajax | 5 - 0 | Heracles Almelo |
| November 21, 2020 | ||
| PEC Zwolle | 1 - 1 | Utrecht |
| Groningen | 1 - 1 | Vitesse |
| Willem II | 2 - 1 | VVV-Venlo |
