| September 20, 2020 | ||
| Ajax | 3 - 0 | RKC Waalwijk |
| Willem II | 4 - 0 | Heracles Almelo |
| Feyenoord | 1 - 1 | Twente |
| ADO Den Haag | 0 - 1 | Groningen |
| September 19, 2020 | ||
| Fortuna Sittard | 1 - 3 | Heerenveen |
| PSV Eindhoven | 2 - 1 | Emmen |
| Vitesse | 2 - 0 | Sparta Rotterdam |
| AZ | 1 - 1 | PEC Zwolle |
| September 18, 2020 | ||
| VVV-Venlo | 1 - 1 | Utrecht |
| September 13, 2020 | ||
| RKC Waalwijk | 0 - 1 | Vitesse |
| Groningen | 1 - 3 | PSV Eindhoven |
| Sparta Rotterdam | 0 - 1 | Ajax |
| Heracles Almelo | 2 - 0 | ADO Den Haag |
| Emmen | 3 - 5 | VVV-Venlo |
| September 12, 2020 | ||
| Twente | 2 - 0 | Fortuna Sittard |
| PEC Zwolle | 0 - 2 | Feyenoord |
| Heerenveen | 2 - 0 | Willem II |
