| February 28, 2021 | ||
| AZ | 4 - 2 | Feyenoord |
| PSV Eindhoven | 1 - 1 | Ajax |
| Groningen | 1 - 0 | Fortuna Sittard |
| Sparta Rotterdam | 0 - 2 | Willem II |
| February 27, 2021 | ||
| Heracles Almelo | 2 - 2 | Twente |
| Vitesse | 4 - 1 | VVV-Venlo |
| ADO Den Haag | 0 - 0 | RKC Waalwijk |
| Utrecht | 0 - 1 | Emmen |
| February 26, 2021 | ||
| PEC Zwolle | 4 - 1 | Heerenveen |
| February 24, 2021 | ||
| Groningen | 0 - 0 | Feyenoord |
| Willem II | 1 - 1 | ADO Den Haag |
| February 21, 2021 | ||
| Ajax | 4 - 2 | Sparta Rotterdam |
| PSV Eindhoven | 3 - 1 | Vitesse |
| Heerenveen | 1 - 1 | Groningen |
| RKC Waalwijk | 3 - 0 | Heracles Almelo |
| Twente | 2 - 2 | Feyenoord |
| February 20, 2021 | ||
| Fortuna Sittard | 2 - 0 | ADO Den Haag |
| VVV-Venlo | 1 - 4 | AZ |
| Emmen | 3 - 2 | PEC Zwolle |
| February 19, 2021 | ||
| Willem II | 0 - 6 | Utrecht |
