| May 9, 2021 | ||
| PEC Zwolle | 0 - 1 | ADO Den Haag |
| Feyenoord | 0 - 3 | Ajax |
| Emmen | 0 - 4 | Groningen |
| May 8, 2021 | ||
| VVV-Venlo | 3 - 3 | RKC Waalwijk |
| AZ | 1 - 0 | Fortuna Sittard |
| Heerenveen | 0 - 0 | Utrecht |
| Twente | 1 - 1 | Heracles Almelo |
| May 7, 2021 | ||
| Sparta Rotterdam | 3 - 0 | Vitesse |
| May 2, 2021 | ||
| PSV Eindhoven | 2 - 2 | Heerenveen |
| Groningen | 1 - 2 | Sparta Rotterdam |
| Ajax | 4 - 0 | Emmen |
| ADO Den Haag | 3 - 2 | Feyenoord |
| May 1, 2021 | ||
| Utrecht | 3 - 2 | Willem II |
| Vitesse | 2 - 1 | PEC Zwolle |
| RKC Waalwijk | 1 - 3 | AZ |
| Fortuna Sittard | 3 - 0 | Twente |
| Heracles Almelo | 4 - 0 | VVV-Venlo |
