| October 2, 2022 | ||
| Emmen | 0 - 0 | Heerenveen |
| RKC Waalwijk | 2 - 2 | Sparta Rotterdam |
| NEC | 1 - 1 | Feyenoord |
| Excelsior | 0 - 1 | Utrecht |
| Fortuna Sittard | 2 - 0 | FC Volendam |
| October 1, 2022 | ||
| Twente | 3 - 0 | Vitesse |
| Ajax | 1 - 1 | Go Ahead Eagles |
| Groningen | 1 - 4 | AZ |
| Cambuur | 3 - 0 | PSV Eindhoven |
| September 18, 2022 | ||
| AZ | 2 - 1 | Ajax |
| Heerenveen | 2 - 1 | Twente |
| PSV Eindhoven | 4 - 3 | Feyenoord |
| Go Ahead Eagles | 2 - 0 | Emmen |
| September 17, 2022 | ||
| Fortuna Sittard | 1 - 0 | Excelsior |
| RKC Waalwijk | 5 - 1 | Cambuur |
| Vitesse | 1 - 1 | FC Volendam |
| Sparta Rotterdam | 2 - 1 | Groningen |
| September 16, 2022 | ||
| Utrecht | 0 - 0 | NEC |
