| January 23, 2022 | ||
| RKC Waalwijk | 2 - 1 | Fortuna Sittard |
| Sparta Rotterdam | 0 - 3 | Utrecht |
| PSV Eindhoven | 1 - 2 | Ajax |
| Heracles Almelo | 1 - 1 | Go Ahead Eagles |
| NEC | 1 - 4 | Feyenoord |
| January 22, 2022 | ||
| Willem II | 0 - 1 | Twente |
| Heerenveen | 0 - 1 | PEC Zwolle |
| AZ | 0 - 0 | Cambuur |
| Vitesse | 1 - 3 | Groningen |
| January 16, 2022 | ||
| Fortuna Sittard | 1 - 2 | AZ |
| Cambuur | 1 - 1 | Sparta Rotterdam |
| Groningen | 0 - 1 | PSV Eindhoven |
| Utrecht | 0 - 3 | Ajax |
| January 15, 2022 | ||
| Go Ahead Eagles | 0 - 2 | RKC Waalwijk |
| Twente | 2 - 0 | Heerenveen |
| Feyenoord | 0 - 1 | Vitesse |
| NEC | 0 - 0 | Heracles Almelo |
| January 14, 2022 | ||
| PEC Zwolle | 2 - 0 | Willem II |
| December 23, 2021 | ||
| Sparta Rotterdam | 1 - 1 | RKC Waalwijk |
| PSV Eindhoven | 2 - 0 | Go Ahead Eagles |
