| October 8, 2022 | ||
| Sassuolo | 15:00 | Inter Milan |
| AC Milan | 18:00 | Juventus |
| Bologna | 20:45 | Sampdoria |
| October 9, 2022 | ||
| Torino | 12:30 | Empoli |
| Monza | 15:00 | Spezia |
| Salernitana | 15:00 | Verona |
| Udinese | 15:00 | Atalanta |
| Cremonese | 18:00 | SSC Napoli |
| Roma | 20:45 | Lecce |
| October 10, 2022 | ||
| Fiorentina | 20:45 | Lazio |
| October 15, 2022 | ||
| Empoli | 15:00 | Monza |
| Torino | 18:00 | Juventus |
| Atalanta | 20:45 | Sassuolo |
| October 16, 2022 | ||
| Inter Milan | 12:30 | Salernitana |
| Lazio | 15:00 | Udinese |
| Spezia | 15:00 | Cremonese |
| SSC Napoli | 18:00 | Bologna |
| Verona | 20:45 | AC Milan |
| October 17, 2022 | ||
| Sampdoria | 18:30 | Roma |
| Lecce | 20:45 | Fiorentina |
