| August 21, 2021 | ||
| Verona | 18:30 | Sassuolo |
| Inter Milan | 18:30 | Genoa |
| Empoli | 20:45 | Lazio |
| Torino | 20:45 | Atalanta |
| August 22, 2021 | ||
| Bologna | 18:30 | Salernitana |
| Udinese | 18:30 | Juventus |
| SSC Napoli | 20:45 | Venezia |
| Roma | 20:45 | Fiorentina |
| August 23, 2021 | ||
| Cagliari | 18:30 | Spezia |
| Sampdoria | 20:45 | AC Milan |
| August 27, 2021 | ||
| Udinese | 18:30 | Venezia |
| Verona | 20:45 | Inter Milan |
| August 28, 2021 | ||
| Atalanta | 18:30 | Bologna |
| Lazio | 18:30 | Spezia |
| Fiorentina | 20:45 | Torino |
| Juventus | 20:45 | Empoli |
| August 29, 2021 | ||
| Genoa | 18:30 | SSC Napoli |
| Sassuolo | 18:30 | Sampdoria |
| AC Milan | 20:45 | Cagliari |
| Salernitana | 20:45 | Roma |
