| December 5, 2020 | ||
| Spezia | 16:00 | Lazio |
| Juventus | 19:00 | Torino |
| Inter Milan | 21:45 | Bologna |
| December 6, 2020 | ||
| Hellas Verona | 13:30 | Cagliari |
| Parma | 16:00 | Benevento |
| Roma | 16:00 | Sassuolo |
| Udinese | 16:00 | Atalanta |
| Crotone | 19:00 | SSC Napoli |
| Sampdoria | 21:45 | Milan |
| December 7, 2020 | ||
| Fiorentina | 21:45 | Genoa |
| December 11, 2020 | ||
| Sassuolo | 21:45 | Benevento |
| December 12, 2020 | ||
| Crotone | 16:00 | Spezia |
| Torino | 19:00 | Udinese |
| Lazio | 21:45 | Hellas Verona |
| December 13, 2020 | ||
| Cagliari | 13:30 | Inter Milan |
| SSC Napoli | 16:00 | Sampdoria |
| Bologna | 16:00 | Roma |
| Atalanta | 16:00 | Fiorentina |
| Genoa | 19:00 | Juventus |
| Milan | 21:45 | Parma |
