| October 16, 2021 | ||
| Spezia | 15:00 | Salernitana |
| Lazio | 18:00 | Inter Milan |
| AC Milan | 20:45 | Verona |
| October 17, 2021 | ||
| Cagliari | 12:30 | Sampdoria |
| Empoli | 15:00 | Atalanta |
| Genoa | 15:00 | Sassuolo |
| Udinese | 15:00 | Bologna |
| SSC Napoli | 18:00 | Torino |
| Juventus | 20:45 | Roma |
| October 18, 2021 | ||
| Venezia | 20:45 | Fiorentina |
| October 22, 2021 | ||
| Torino | 18:30 | Genoa |
| Sampdoria | 20:45 | Spezia |
| October 23, 2021 | ||
| Salernitana | 15:00 | Empoli |
| Sassuolo | 18:00 | Venezia |
| Bologna | 20:45 | AC Milan |
| October 24, 2021 | ||
| Atalanta | 12:30 | Udinese |
| Fiorentina | 15:00 | Cagliari |
| Verona | 15:00 | Lazio |
| Roma | 18:00 | SSC Napoli |
| Inter Milan | 20:45 | Juventus |
