| January 6, 2022 | ||
| Bologna | 13:30 | Inter Milan |
| Atalanta | 17:30 | Torino |
| Salernitana | 19:30 | Venezia |
| Fiorentina | 21:45 | Udinese |
| February 5, 2022 | ||
| Roma | 16:00 | Genoa |
| Inter Milan | 19:00 | AC Milan |
| Fiorentina | 21:45 | Lazio |
| February 6, 2022 | ||
| Atalanta | 13:30 | Cagliari |
| Venezia | 16:00 | SSC Napoli |
| Sampdoria | 16:00 | Sassuolo |
| Bologna | 16:00 | Empoli |
| Udinese | 19:00 | Torino |
| Juventus | 21:45 | Verona |
| February 7, 2022 | ||
| Salernitana | 21:45 | Spezia |
| February 12, 2022 | ||
| Lazio | 16:00 | Bologna |
| SSC Napoli | 19:00 | Inter Milan |
| Torino | 21:45 | Venezia |
