| May 9, 2021 | ||
| Roma | 18:00 | Crotone |
| Juventus | 20:45 | Milan |
| May 11, 2021 | ||
| SSC Napoli | 20:45 | Udinese |
| May 12, 2021 | ||
| Cagliari | 18:30 | Fiorentina |
| Atalanta | 20:45 | Benevento |
| Bologna | 20:45 | Genoa |
| Sassuolo | 20:45 | Juventus |
| Torino | 20:45 | Milan |
| Lazio | 20:45 | Parma |
| Inter Milan | 20:45 | Roma |
| Sampdoria | 20:45 | Spezia |
| May 13, 2021 | ||
| Crotone | 20:45 | Hellas Verona |
| May 15, 2021 | ||
| Genoa | 15:00 | Atalanta |
| Spezia | 15:00 | Torino |
| Juventus | 18:00 | Inter Milan |
| Roma | 20:45 | Lazio |
