| March 2, 2021 | ||
| Lazio | 19:30 | Torino |
| March 4, 2021 | ||
| Parma | 21:45 | Inter Milan |
| March 6, 2021 | ||
| Spezia | 16:00 | Benevento |
| Udinese | 19:00 | Sassuolo |
| Juventus | 21:45 | Lazio |
| March 7, 2021 | ||
| Roma | 13:30 | Genoa |
| Hellas Verona | 16:00 | Milan |
| Fiorentina | 16:00 | Parma |
| Crotone | 16:00 | Torino |
| Sampdoria | 19:00 | Cagliari |
| SSC Napoli | 21:45 | Bologna |
| March 8, 2021 | ||
| Inter Milan | 21:45 | Atalanta |
| March 12, 2021 | ||
| Lazio | 16:00 | Crotone |
| Atalanta | 21:45 | Spezia |
| March 13, 2021 | ||
| Sassuolo | 16:00 | Hellas Verona |
| Benevento | 19:00 | Fiorentina |
| Genoa | 21:45 | Udinese |
