| August 14, 2022 | ||
| Athletic Bilbao | 02:00 | Mallorca |
| Real Betis | 02:00 | Elche |
| Celta Vigo | 02:00 | Espanyol |
| Cadiz | 02:00 | Real Sociedad |
| Osasuna | 02:00 | Sevilla |
| Almeria | 02:00 | Real Madrid |
| Getafe | 02:00 | Atlético de Madrid |
| Real Valladolid | 02:00 | Villarreal |
| Valencia | 02:00 | Girona |
| Barcelona | 02:00 | Rayo Vallecano |
| August 21, 2022 | ||
| Mallorca | 02:00 | Real Betis |
| Elche | 02:00 | Almeria |
| Osasuna | 02:00 | Cadiz |
| Girona | 02:00 | Getafe |
| Celta Vigo | 02:00 | Real Madrid |
| Real Sociedad | 02:00 | Barcelona |
| Sevilla | 02:00 | Real Valladolid |
| Espanyol | 02:00 | Rayo Vallecano |
| Atlético de Madrid | 02:00 | Villarreal |
| Athletic Bilbao | 02:00 | Valencia |
