| January 19, 2022 | ||
| Barcelona | 02:00 | Rayo Vallecano |
| January 20, 2022 | ||
| Mallorca | 20:00 | Real Sociedad |
| February 4, 2022 | ||
| Getafe | 22:00 | Levante |
| February 5, 2022 | ||
| Elche | 15:00 | Alaves |
| Mallorca | 17:15 | Cadiz |
| Celta Vigo | 19:30 | Rayo Vallecano |
| Osasuna | 22:00 | Sevilla |
| February 6, 2022 | ||
| Valencia | 15:00 | Real Sociedad |
| Barcelona | 17:15 | Atlético de Madrid |
| Real Betis | 19:30 | Villarreal |
| Real Madrid | 22:00 | Granada |
| February 7, 2022 | ||
| Athletic Bilbao | 22:00 | Espanyol |
| February 11, 2022 | ||
| Sevilla | 22:00 | Elche |
| February 12, 2022 | ||
| Cadiz | 15:00 | Celta Vigo |
| Villarreal | 17:15 | Real Madrid |
| Rayo Vallecano | 19:30 | Osasuna |
| Atlético de Madrid | 22:00 | Getafe |
