| May 21, 2021 | ||
| Levante | 21:00 | Cádiz |
| May 22, 2021 | ||
| Celta Vigo | 18:00 | Real Betis |
| Eibar | 18:00 | Barcelona |
| Huesca | 18:00 | Valencia |
| Osasuna | 18:00 | Real Sociedad |
| Real Madrid | 18:00 | Villarreal |
| Real Valladolid | 18:00 | Atlético de Madrid |
| Elche | 18:00 | Athletic Bilbao |
| May 23, 2021 | ||
| Granada | 18:30 | Getafe |
| Sevilla | 21:00 | Deportivo Alavés |
