| August 13, 2021 | ||
| Valencia | 21:00 | Getafe |
| August 14, 2021 | ||
| Osasuna | 17:00 | Espanyol |
| Mallorca | 19:30 | Real Betis |
| Cadiz | 19:30 | Levante |
| Alaves | 22:00 | Real Madrid |
| August 15, 2021 | ||
| Celta Vigo | 17:30 | Atlético de Madrid |
| Barcelona | 20:00 | Real Sociedad |
| Sevilla | 22:15 | Rayo Vallecano |
| August 16, 2021 | ||
| Villarreal | 20:00 | Granada |
| Elche | 22:00 | Athletic Bilbao |
| August 20, 2021 | ||
| Real Betis | 21:00 | Cadiz |
| August 21, 2021 | ||
| Alaves | 17:00 | Mallorca |
| Granada | 19:30 | Valencia |
| Espanyol | 19:30 | Villarreal |
| Athletic Bilbao | 22:00 | Barcelona |
| August 22, 2021 | ||
| Real Sociedad | 17:00 | Rayo Vallecano |
| Atlético de Madrid | 19:30 | Elche |
| Levante | 22:00 | Real Madrid |
| August 23, 2021 | ||
| Getafe | 20:00 | Sevilla |
| Osasuna | 22:00 | Celta Vigo |
