| September 13, 2020 | ||
| Barcelona | 02:00 | Elche |
| Real Madrid | 02:00 | Getafe |
| September 20, 2020 | ||
| Levante | 02:00 | Atlético de Madrid |
| Sevilla | 02:00 | Elche |
| September 26, 2020 | ||
| Deportivo Alavés | 13:00 | Getafe |
| Valencia | 16:00 | Huesca |
| Elche | 18:30 | Real Sociedad |
| Real Betis | 21:00 | Real Madrid |
| September 27, 2020 | ||
| Osasuna | 12:00 | Levante |
| Eibar | 14:00 | Athletic Bilbao |
| Atlético de Madrid | 16:00 | Granada |
| Cádiz | 18:30 | Sevilla |
| Real Valladolid | 18:30 | Celta Vigo |
| Barcelona | 21:00 | Villarreal |
| September 29, 2020 | ||
| Real Sociedad | 19:00 | Valencia |
| Getafe | 21:30 | Real Betis |
| September 30, 2020 | ||
| Huesca | 19:00 | Atlético de Madrid |
| Villarreal | 19:00 | Deportivo Alavés |
| Eibar | 21:30 | Elche |
| Real Madrid | 21:30 | Real Valladolid |
