| March 7, 2021 | ||
| Athletic Bilbao | 22:00 | Granada |
| March 8, 2021 | ||
| Real Betis | 22:00 | Deportivo Alavés |
| March 10, 2021 | ||
| Atlético de Madrid | 20:00 | Athletic Bilbao |
| March 12, 2021 | ||
| Levante | 22:00 | Valencia |
| March 13, 2021 | ||
| Deportivo Alavés | 15:00 | Cádiz |
| Real Madrid | 17:15 | Elche |
| Osasuna | 19:30 | Real Valladolid |
| Getafe | 22:00 | Atlético de Madrid |
| March 14, 2021 | ||
| Celta Vigo | 15:00 | Athletic Bilbao |
| Granada | 17:15 | Real Sociedad |
| Eibar | 19:30 | Villarreal |
| Sevilla | 22:00 | Real Betis |
| March 15, 2021 | ||
| Barcelona | 22:00 | Huesca |
| March 17, 2021 | ||
| Sevilla | 20:00 | Elche |
| March 19, 2021 | ||
| Real Betis | 22:00 | Levante |
| March 20, 2021 | ||
| Athletic Bilbao | 15:00 | Eibar |
| Celta Vigo | 17:15 | Real Madrid |
| Huesca | 19:30 | Osasuna |
| Real Valladolid | 22:00 | Sevilla |
