| October 2, 2022 | ||
| Celta Vigo | 16:15 | Real Betis |
| Girona | 18:30 | Real Sociedad |
| Real Madrid | 21:00 | Osasuna |
| October 3, 2022 | ||
| Rayo Vallecano | 21:00 | Elche |
| October 7, 2022 | ||
| Osasuna | 21:00 | Valencia |
| October 8, 2022 | ||
| Almeria | 14:00 | Rayo Vallecano |
| Atlético de Madrid | 16:15 | Girona |
| Sevilla | 18:30 | Athletic Bilbao |
| Getafe | 21:00 | Real Madrid |
| October 9, 2022 | ||
| Real Valladolid | 14:00 | Real Betis |
| Cadiz | 16:15 | Espanyol |
| Real Sociedad | 18:30 | Villarreal |
| Barcelona | 21:00 | Celta Vigo |
| October 10, 2022 | ||
| Elche | 21:00 | Mallorca |
| October 14, 2022 | ||
| Rayo Vallecano | 21:00 | Getafe |
| October 15, 2022 | ||
| Girona | 14:00 | Cadiz |
| Valencia | 16:15 | Elche |
| Mallorca | 18:30 | Sevilla |
| Athletic Bilbao | 21:00 | Atlético de Madrid |
