| December 4, 2020 | ||
| Sparta Rotterdam | 21:00 | Emmen |
| December 5, 2020 | ||
| RKC Waalwijk | 17:30 | VVV-Venlo |
| Fortuna Sittard | 19:45 | Willem II |
| Ajax | 21:00 | Twente |
| PEC Zwolle | 22:00 | Vitesse |
| December 6, 2020 | ||
| Feyenoord | 13:15 | Heracles Almelo |
| AZ | 15:30 | Groningen |
| Utrecht | 15:30 | ADO Den Haag |
| Heerenveen | 17:45 | PSV Eindhoven |
| December 11, 2020 | ||
| Heracles Almelo | 21:00 | Fortuna Sittard |
| December 12, 2020 | ||
| Groningen | 17:30 | RKC Waalwijk |
| Emmen | 19:45 | ADO Den Haag |
| Ajax | 21:00 | PEC Zwolle |
| December 13, 2020 | ||
| Vitesse | 13:15 | Heerenveen |
| VVV-Venlo | 15:30 | Feyenoord |
| Willem II | 15:30 | Sparta Rotterdam |
| PSV Eindhoven | 17:45 | Utrecht |
| Twente | 21:00 | AZ |
| December 18, 2020 | ||
| PEC Zwolle | 21:00 | Emmen |
