| August 5, 2022 | ||
| Heerenveen | 20:00 | Sparta Rotterdam |
| August 6, 2022 | ||
| Fortuna Sittard | 16:30 | Ajax |
| Cambuur | 18:45 | Excelsior |
| PSV Eindhoven | 20:00 | Emmen |
| RKC Waalwijk | 21:00 | Utrecht |
| August 7, 2022 | ||
| Groningen | 12:15 | FC Volendam |
| Vitesse | 14:30 | Feyenoord |
| NEC | 14:30 | Twente |
| AZ | 16:45 | Go Ahead Eagles |
| August 12, 2022 | ||
| Excelsior | 20:00 | Vitesse |
| August 13, 2022 | ||
| Go Ahead Eagles | 18:45 | PSV Eindhoven |
| Emmen | 20:00 | RKC Waalwijk |
| Utrecht | 20:00 | Cambuur |
| Feyenoord | 21:00 | Heerenveen |
| August 14, 2022 | ||
| FC Volendam | 12:15 | NEC |
| Ajax | 14:30 | Groningen |
| Twente | 14:30 | Fortuna Sittard |
| Sparta Rotterdam | 16:45 | AZ |
