| February 5, 2022 | ||
| Utrecht | 17:30 | Cambuur |
| Fortuna Sittard | 19:45 | Heerenveen |
| PEC Zwolle | 21:00 | NEC |
| PSV Eindhoven | 21:00 | AZ |
| Twente | 22:00 | Vitesse |
| February 6, 2022 | ||
| Feyenoord | 13:15 | Sparta Rotterdam |
| Groningen | 15:30 | Go Ahead Eagles |
| Willem II | 15:30 | RKC Waalwijk |
| Ajax | 17:45 | Heracles Almelo |
| February 11, 2022 | ||
| Heracles Almelo | 21:00 | Utrecht |
| February 12, 2022 | ||
| Groningen | 19:45 | Fortuna Sittard |
| Vitesse | 21:00 | PSV Eindhoven |
| Cambuur | 22:00 | PEC Zwolle |
| February 13, 2022 | ||
| Sparta Rotterdam | 13:15 | Willem II |
| Heerenveen | 15:30 | NEC |
| RKC Waalwijk | 15:30 | Feyenoord |
| Ajax | 17:45 | Twente |
| Go Ahead Eagles | 17:45 | AZ |
| February 18, 2022 | ||
| Fortuna Sittard | 21:00 | Sparta Rotterdam |
