| September 26, 2020 | ||
| PEC Zwolle | 16:30 | Sparta Rotterdam |
| Fortuna Sittard | 18:45 | AZ |
| Heerenveen | 20:00 | VVV-Venlo |
| Ajax | 21:00 | Vitesse |
| September 27, 2020 | ||
| Feyenoord | 12:15 | ADO Den Haag |
| Utrecht | 14:30 | RKC Waalwijk |
| Heracles Almelo | 16:45 | PSV Eindhoven |
| Emmen | 16:45 | Willem II |
| October 2, 2020 | ||
| Utrecht | 20:00 | Heerenveen |
| October 3, 2020 | ||
| Vitesse | 16:30 | Heracles Almelo |
| RKC Waalwijk | 18:45 | PEC Zwolle |
| VVV-Venlo | 20:00 | ADO Den Haag |
| Twente | 21:00 | Emmen |
| October 4, 2020 | ||
| Groningen | 12:15 | Ajax |
| Sparta Rotterdam | 14:30 | AZ |
| Willem II | 14:30 | Feyenoord |
| PSV Eindhoven | 16:45 | Fortuna Sittard |
