| February 7, 2021 | ||
| Ajax | 13:15 | Utrecht |
| March 5, 2021 | ||
| Emmen | 21:00 | Sparta Rotterdam |
| March 6, 2021 | ||
| Feyenoord | 17:30 | VVV-Venlo |
| Twente | 19:45 | Willem II |
| Heerenveen | 21:00 | ADO Den Haag |
| RKC Waalwijk | 22:00 | Utrecht |
| March 7, 2021 | ||
| Ajax | 13:15 | Groningen |
| Fortuna Sittard | 15:30 | PSV Eindhoven |
| Heracles Almelo | 15:30 | PEC Zwolle |
| Vitesse | 17:45 | AZ |
| March 9, 2021 | ||
| VVV-Venlo | 19:45 | Sparta Rotterdam |
| March 13, 2021 | ||
| Willem II | 17:30 | Heerenveen |
| ADO Den Haag | 19:45 | Heracles Almelo |
| AZ | 21:00 | Twente |
| Groningen | 21:00 | Emmen |
| Sparta Rotterdam | 22:00 | RKC Waalwijk |
| March 14, 2021 | ||
| VVV-Venlo | 13:15 | Fortuna Sittard |
| Utrecht | 15:30 | Vitesse |
| PSV Eindhoven | 15:30 | Feyenoord |
| PEC Zwolle | 17:45 | Ajax |
