| October 2, 2022 | ||
| RKC Waalwijk | 16:45 | Sparta Rotterdam |
| Emmen | 20:00 | Heerenveen |
| October 7, 2022 | ||
| Groningen | 20:00 | RKC Waalwijk |
| October 8, 2022 | ||
| FC Volendam | 16:30 | Ajax |
| Sparta Rotterdam | 18:45 | Emmen |
| NEC | 21:00 | Excelsior |
| October 9, 2022 | ||
| Go Ahead Eagles | 12:15 | Cambuur |
| Feyenoord | 14:30 | Twente |
| Utrecht | 14:30 | AZ |
| Heerenveen | 16:45 | PSV Eindhoven |
| Vitesse | 20:00 | Fortuna Sittard |
| October 14, 2022 | ||
| Emmen | 20:00 | FC Volendam |
| October 15, 2022 | ||
| Fortuna Sittard | 18:45 | RKC Waalwijk |
| Go Ahead Eagles | 20:00 | Heerenveen |
| Cambuur | 21:00 | Vitesse |
| October 16, 2022 | ||
| Sparta Rotterdam | 12:15 | NEC |
| Twente | 14:30 | Groningen |
| PSV Eindhoven | 14:30 | Utrecht |
| AZ | 16:45 | Feyenoord |
| Ajax | 20:00 | Excelsior |
