| May 9, 2021 | ||
| Willem II | 16:45 | PSV Eindhoven |
| May 13, 2021 | ||
| Ajax | 14:30 | VVV-Venlo |
| Emmen | 14:30 | Heerenveen |
| Groningen | 14:30 | AZ |
| Fortuna Sittard | 14:30 | Vitesse |
| Heracles Almelo | 14:30 | Feyenoord |
| PSV Eindhoven | 14:30 | PEC Zwolle |
| RKC Waalwijk | 14:30 | Twente |
| Sparta Rotterdam | 14:30 | Utrecht |
| ADO Den Haag | 14:30 | Willem II |
| May 16, 2021 | ||
| Heerenveen | 14:30 | Sparta Rotterdam |
| Willem II | 14:30 | Fortuna Sittard |
| VVV-Venlo | 14:30 | Emmen |
| Vitesse | 14:30 | Ajax |
| AZ | 14:30 | Heracles Almelo |
| PEC Zwolle | 14:30 | Groningen |
| Feyenoord | 14:30 | RKC Waalwijk |
| Utrecht | 14:30 | PSV Eindhoven |
| Twente | 14:30 | ADO Den Haag |
