| December 4, 2020 | ||
| Hertha BSC | 21:30 | Union Berlin |
| December 5, 2020 | ||
| SC Freiburg | 16:30 | Borussia Mönchengladbach |
| Eintracht Frankfurt | 16:30 | Borussia Dortmund |
| 1. FC Köln | 16:30 | Wolfsburg |
| Arminia Bielefeld | 16:30 | 1. FSV Mainz 05 |
| Bayern Munich | 19:30 | RB Leipzig |
| December 6, 2020 | ||
| Werder Bremen | 16:30 | Stuttgart |
| Schalke 04 | 19:00 | Bayer 04 Leverkusen |
| December 7, 2020 | ||
| TSG 1899 Hoffenheim | 21:30 | Augsburg 1907 |
| December 11, 2020 | ||
| Wolfsburg | 21:30 | Eintracht Frankfurt |
| December 12, 2020 | ||
| Borussia Dortmund | 16:30 | Stuttgart |
| RB Leipzig | 16:30 | Werder Bremen |
| Borussia Mönchengladbach | 16:30 | Hertha BSC |
| SC Freiburg | 16:30 | Arminia Bielefeld |
| 1. FSV Mainz 05 | 16:30 | 1. FC Köln |
| Union Berlin | 19:30 | Bayern Munich |
| December 13, 2020 | ||
| Augsburg 1907 | 16:30 | Schalke 04 |
| Bayer 04 Leverkusen | 19:00 | TSG 1899 Hoffenheim |
