| March 5, 2021 | ||
| Schalke 04 | 21:30 | 1. FSV Mainz 05 |
| March 6, 2021 | ||
| Borussia Mönchengladbach | 16:30 | Bayer 04 Leverkusen |
| TSG 1899 Hoffenheim | 16:30 | Wolfsburg |
| SC Freiburg | 16:30 | RB Leipzig |
| Eintracht Frankfurt | 16:30 | Stuttgart |
| Hertha BSC | 16:30 | Augsburg 1907 |
| Bayern Munich | 19:30 | Borussia Dortmund |
| March 7, 2021 | ||
| 1. FC Köln | 16:30 | Werder Bremen |
| Arminia Bielefeld | 19:00 | Union Berlin |
| March 10, 2021 | ||
| Arminia Bielefeld | 19:30 | Werder Bremen |
| March 12, 2021 | ||
| Augsburg 1907 | 21:30 | Borussia Mönchengladbach |
| March 13, 2021 | ||
| Werder Bremen | 16:30 | Bayern Munich |
| Union Berlin | 16:30 | 1. FC Köln |
| 1. FSV Mainz 05 | 16:30 | SC Freiburg |
| Wolfsburg | 16:30 | Schalke 04 |
| Borussia Dortmund | 19:30 | Hertha BSC |
| March 14, 2021 | ||
| Bayer 04 Leverkusen | 14:30 | Arminia Bielefeld |
| RB Leipzig | 16:30 | Eintracht Frankfurt |
| Stuttgart | 19:00 | TSG 1899 Hoffenheim |
| March 19, 2021 | ||
| Arminia Bielefeld | 21:30 | RB Leipzig |
