| February 4, 2022 | ||
| Hertha Berlin | 21:30 | VFL Bochum |
| February 5, 2022 | ||
| Stuttgart | 16:30 | Eintracht Frankfurt |
| Mainz | 16:30 | TSG 1899 Hoffenheim |
| Augsburg 1907 | 16:30 | Union Berlin |
| Arminia Bielefeld | 16:30 | Borussia Mönchengladbach |
| FC Cologne | 16:30 | SC Freiburg |
| Bayern Munich | 19:30 | RB Leipzig |
| February 6, 2022 | ||
| Borussia Dortmund | 16:30 | Bayer 04 Leverkusen |
| Wolfsburg | 18:30 | Greuther Fürth |
| February 11, 2022 | ||
| RB Leipzig | 21:30 | FC Cologne |
| February 12, 2022 | ||
| Eintracht Frankfurt | 16:30 | Wolfsburg |
| Borussia Mönchengladbach | 16:30 | Augsburg 1907 |
| SC Freiburg | 16:30 | Mainz |
| VFL Bochum | 16:30 | Bayern Munich |
| Greuther Fürth | 16:30 | Hertha Berlin |
| Bayer 04 Leverkusen | 19:30 | Stuttgart |
| February 13, 2022 | ||
| Union Berlin | 16:30 | Borussia Dortmund |
| TSG 1899 Hoffenheim | 18:30 | Arminia Bielefeld |
| February 18, 2022 | ||
| Mainz | 21:30 | Bayer 04 Leverkusen |
