| August 13, 2021 | ||
| Borussia Mönchengladbach | 20:30 | Bayern Munich |
| August 14, 2021 | ||
| Augsburg 1907 | 15:30 | TSG 1899 Hoffenheim |
| Arminia Bielefeld | 15:30 | SC Freiburg |
| Wolfsburg | 15:30 | VFL Bochum |
| Stuttgart | 15:30 | Greuther Fürth |
| Union Berlin | 15:30 | Bayer 04 Leverkusen |
| Borussia Dortmund | 18:30 | Eintracht Frankfurt |
| August 15, 2021 | ||
| Mainz | 15:30 | RB Leipzig |
| FC Cologne | 17:30 | Hertha Berlin |
| August 20, 2021 | ||
| RB Leipzig | 20:30 | Stuttgart |
| August 21, 2021 | ||
| Greuther Fürth | 15:30 | Arminia Bielefeld |
| VFL Bochum | 15:30 | Mainz |
| Hertha Berlin | 15:30 | Wolfsburg |
| SC Freiburg | 15:30 | Borussia Dortmund |
| Eintracht Frankfurt | 15:30 | Augsburg 1907 |
| Bayer 04 Leverkusen | 18:30 | Borussia Mönchengladbach |
| August 22, 2021 | ||
| TSG 1899 Hoffenheim | 15:30 | Union Berlin |
| Bayern Munich | 17:30 | FC Cologne |
| August 27, 2021 | ||
| Borussia Dortmund | 20:30 | TSG 1899 Hoffenheim |
