| May 9, 2021 | ||
| Eintracht Frankfurt | 15:30 | 1. FSV Mainz 05 |
| Hertha BSC | 18:00 | Arminia Bielefeld |
| May 12, 2021 | ||
| Schalke 04 | 18:00 | Hertha BSC |
| May 15, 2021 | ||
| Borussia Mönchengladbach | 15:30 | Stuttgart |
| Bayer 04 Leverkusen | 15:30 | Union Berlin |
| SC Freiburg | 15:30 | Bayern Munich |
| Hertha BSC | 15:30 | 1. FC Köln |
| Schalke 04 | 15:30 | Eintracht Frankfurt |
| Augsburg 1907 | 15:30 | Werder Bremen |
| Arminia Bielefeld | 15:30 | TSG 1899 Hoffenheim |
| May 16, 2021 | ||
| 1. FSV Mainz 05 | 18:00 | Borussia Dortmund |
| RB Leipzig | 20:30 | Wolfsburg |
