| October 2, 2022 | ||
| Hertha Berlin | 15:30 | TSG 1899 Hoffenheim |
| Schalke 04 | 17:30 | Augsburg 1907 |
| October 7, 2022 | ||
| TSG 1899 Hoffenheim | 20:30 | Werder Bremen |
| October 8, 2022 | ||
| Bayer 04 Leverkusen | 15:30 | Schalke 04 |
| Mainz | 15:30 | RB Leipzig |
| VFL Bochum | 15:30 | Eintracht Frankfurt |
| Augsburg 1907 | 15:30 | Wolfsburg |
| Borussia Dortmund | 18:30 | Bayern Munich |
| October 9, 2022 | ||
| Borussia Mönchengladbach | 15:30 | FC Cologne |
| Hertha Berlin | 17:30 | SC Freiburg |
| Stuttgart | 19:30 | Union Berlin |
| October 14, 2022 | ||
| Schalke 04 | 20:30 | TSG 1899 Hoffenheim |
| October 15, 2022 | ||
| Werder Bremen | 15:30 | Mainz |
| Stuttgart | 15:30 | VFL Bochum |
| Wolfsburg | 15:30 | Borussia Mönchengladbach |
| Eintracht Frankfurt | 15:30 | Bayer 04 Leverkusen |
| RB Leipzig | 18:30 | Hertha Berlin |
| October 16, 2022 | ||
| FC Cologne | 15:30 | Augsburg 1907 |
| Union Berlin | 17:30 | Borussia Dortmund |
| Bayern Munich | 19:30 | SC Freiburg |
