| October 3, 2021 | ||
| Rangers | 2 - 1 | Hibernian |
| Aberdeen | 1 - 2 | Celtic |
| October 2, 2021 | ||
| St. Johnstone | 3 - 1 | Dundee |
| Livingston | 0 - 1 | St. Mirren |
| Hearts | 2 - 0 | Motherwell |
| Dundee United | 1 - 0 | Ross County |
| September 26, 2021 | ||
| Hibernian | 1 - 0 | St. Johnstone |
| Celtic | 1 - 1 | Dundee United |
| St. Mirren | 3 - 2 | Aberdeen |
| September 25, 2021 | ||
| Dundee | 0 - 1 | Rangers |
| Hearts | 3 - 0 | Livingston |
| Motherwell | 2 - 1 | Ross County |
| September 19, 2021 | ||
| Rangers | 1 - 1 | Motherwell |
| Livingston | 1 - 0 | Celtic |
| Dundee United | 1 - 0 | Dundee |
| September 18, 2021 | ||
| Ross County | 2 - 2 | Hearts |
| Hibernian | 2 - 2 | St. Mirren |
| Aberdeen | 0 - 1 | St. Johnstone |
| September 12, 2021 | ||
| Hearts | 0 - 0 | Hibernian |
