| October 15, 2021 | ||
| Paris Saint-Germain | 2 - 1 | Angers |
| October 3, 2021 | ||
| Saint-Etienne | 1 - 1 | Lyon |
| LOSC Lille Métropole | 2 - 0 | Marseille |
| Nantes | 2 - 0 | ESTAC |
| Monaco | 3 - 0 | Girondins de Bordeaux |
| Lorient | 1 - 1 | Clermont |
| Angers | 3 - 2 | Metz |
| Stade Rennais FC | 2 - 0 | Paris Saint-Germain |
| October 2, 2021 | ||
| OGC Nice | 2 - 1 | Brest |
| Montpellier Hérault SC | 1 - 1 | Strasbourg |
| October 1, 2021 | ||
| Lens | 2 - 0 | Stade de Reims |
| September 26, 2021 | ||
| Marseille | 2 - 3 | Lens |
| Clermont | 1 - 3 | Monaco |
| ESTAC | 1 - 1 | Angers |
| Stade de Reims | 3 - 1 | Nantes |
| Brest | 1 - 2 | Metz |
| Girondins de Bordeaux | 1 - 1 | Stade Rennais FC |
