| January 26, 2022 | ||
| Angers | 0 - 1 | Saint-Etienne |
| January 23, 2022 | ||
| Paris Saint-Germain | 4 - 0 | Stade de Reims |
| Montpellier Hérault SC | 3 - 2 | Monaco |
| Nantes | 4 - 2 | Lorient |
| Clermont | 2 - 1 | Stade Rennais FC |
| Girondins de Bordeaux | 4 - 3 | Strasbourg |
| Angers | 2 - 1 | ESTAC |
| Metz | 0 - 2 | OGC Nice |
| January 22, 2022 | ||
| Lens | 0 - 2 | Marseille |
| Brest | 2 - 0 | LOSC Lille Métropole |
| January 21, 2022 | ||
| Lyon | 1 - 0 | Saint-Etienne |
| January 19, 2022 | ||
| Clermont | 0 - 2 | Strasbourg |
| LOSC Lille Métropole | 3 - 1 | Lorient |
| Montpellier Hérault SC | 0 - 1 | ESTAC |
