| March 3, 2021 | ||
| Strasbourg | 1 - 0 | Monaco |
| Nantes | 1 - 2 | Stade de Reims |
| Montpellier Hérault SC | 1 - 1 | Lorient |
| LOSC Lille Métropole | 2 - 0 | Olympique de Marseille |
| Girondins de Bordeaux | 0 - 1 | Paris Saint-Germain |
| Saint-Etienne | 2 - 3 | Lens |
| OGC Nice | 2 - 1 | Nîmes |
| Metz | 0 - 1 | Angers SCO |
| Olympique Lyonnais | 1 - 0 | Stade Rennais FC |
| Brest | 3 - 1 | Dijon |
| February 28, 2021 | ||
| Olympique de Marseille | 1 - 1 | Olympique Lyonnais |
| LOSC Lille Métropole | 1 - 1 | Strasbourg |
| Lorient | 2 - 1 | Saint-Etienne |
| Angers SCO | 2 - 2 | Lens |
| Nîmes | 1 - 1 | Nantes |
| Stade de Reims | 0 - 0 | Montpellier Hérault SC |
| Monaco | 2 - 0 | Brest |
| February 27, 2021 | ||
| Dijon | 0 - 4 | Paris Saint-Germain |
| Girondins de Bordeaux | 1 - 2 | Metz |
| February 26, 2021 | ||
| Stade Rennais FC | 1 - 2 | OGC Nice |
