| January 23, 2022 | ||
| Porto | 3 - 1 | Famalicão |
| Gil Vicente | 1 - 0 | Portimonense |
| Vitoria Guimaraes | 3 - 1 | Estoril |
| Marítimo | 1 - 1 | Belenenses |
| January 22, 2022 | ||
| Sporting Lisbon | 1 - 2 | SC Braga |
| Tondela | 2 - 3 | Vizela |
| Moreirense | 0 - 2 | Santa Clara |
| January 21, 2022 | ||
| Paços Ferreira | 1 - 1 | Boavista |
| Arouca | 0 - 2 | Benfica |
| January 17, 2022 | ||
| Portimonense | 1 - 1 | Vitoria Guimaraes |
| January 16, 2022 | ||
| Belenenses | 1 - 4 | Porto |
| Famalicão | 0 - 0 | Paços Ferreira |
| Vizela | 0 - 2 | Sporting Lisbon |
| Santa Clara | 2 - 2 | Tondela |
| January 15, 2022 | ||
| SC Braga | 0 - 1 | Marítimo |
| Benfica | 1 - 1 | Moreirense |
| Boavista | 1 - 1 | Gil Vicente |
| January 13, 2022 | ||
| Famalicão | 1 - 0 | Belenenses |
| January 10, 2022 | ||
| Gil Vicente | 3 - 2 | Vitoria Guimaraes |
