| October 3, 2022 | ||
| Marítimo | 1 - 2 | Casa Pia |
| October 2, 2022 | ||
| Famalicão | 4 - 0 | Boavista |
| Paços Ferreira | 1 - 1 | Arouca |
| Rio Ave | 1 - 0 | Santa Clara |
| October 1, 2022 | ||
| Vitoria Guimaraes | 0 - 0 | Benfica |
| Chaves | 1 - 1 | Estoril |
| Vizela | 1 - 0 | Portimonense |
| September 30, 2022 | ||
| Porto | 4 - 1 | SC Braga |
| Sporting Lisbon | 3 - 1 | Gil Vicente |
| September 18, 2022 | ||
| SC Braga | 2 - 0 | Vizela |
| Benfica | 5 - 0 | Marítimo |
| Casa Pia | 1 - 0 | Famalicão |
| Arouca | 2 - 2 | Vitoria Guimaraes |
| September 17, 2022 | ||
| Boavista | 2 - 1 | Sporting Lisbon |
| Estoril | 1 - 1 | Porto |
| Gil Vicente | 2 - 2 | Rio Ave |
| Santa Clara | 1 - 1 | Paços Ferreira |
| September 16, 2022 | ||
| Portimonense | 1 - 0 | Chaves |
| September 12, 2022 | ||
| Vizela | 0 - 1 | Estoril |
