| October 3, 2021 | ||
| SC Braga | 2 - 2 | Boavista |
| Estoril | 2 - 2 | Gil Vicente |
| Benfica | 0 - 1 | Portimonense |
| Belenenses | 0 - 2 | Tondela |
| October 2, 2021 | ||
| Arouca | 1 - 2 | Sporting Lisbon |
| Porto | 2 - 1 | Paços Ferreira |
| Vizela | 1 - 1 | Santa Clara |
| October 1, 2021 | ||
| Famalicão | 1 - 2 | Vitoria Guimaraes |
| Marítimo | 0 - 0 | Moreirense |
| September 27, 2021 | ||
| Boavista | 1 - 1 | Estoril |
| Paços Ferreira | 2 - 2 | Belenenses |
| September 26, 2021 | ||
| Portimonense | 0 - 0 | Vizela |
| Santa Clara | 1 - 1 | SC Braga |
| September 25, 2021 | ||
| Tondela | 3 - 2 | Famalicão |
| Vitoria Guimaraes | 1 - 3 | Benfica |
| Moreirense | 2 - 1 | Arouca |
| September 24, 2021 | ||
| Gil Vicente | 1 - 2 | Porto |
| Sporting Lisbon | 1 - 0 | Marítimo |
| September 20, 2021 | ||
| SC Braga | 3 - 1 | Tondela |
| Benfica | 3 - 1 | Boavista |
