| March 1, 2021 | ||
| Moreirense | 2 - 2 | Belenenses |
| Benfica | 2 - 0 | Rio Ave |
| February 28, 2021 | ||
| Nacional | 1 - 2 | SC Braga |
| Tondela | 1 - 0 | Gil Vicente |
| Portimonense | 0 - 0 | Marítimo |
| February 27, 2021 | ||
| Porto | 0 - 0 | Sporting CP |
| Santa Clara | 3 - 0 | Paços de Ferreira |
| Famalicão | 0 - 0 | Farense |
| February 26, 2021 | ||
| Vitoria Guimaraes | 2 - 1 | Boavista |
| February 22, 2021 | ||
| Marítimo | 1 - 2 | Porto |
| February 21, 2021 | ||
| Farense | 0 - 0 | Benfica |
| SC Braga | 4 - 2 | Tondela |
| Paços de Ferreira | 2 - 1 | Vitoria Guimaraes |
| Rio Ave | 0 - 1 | Famalicão |
| February 20, 2021 | ||
| Sporting CP | 2 - 0 | Portimonense |
| Gil Vicente | 1 - 0 | Santa Clara |
| Belenenses | 2 - 1 | Nacional |
| February 19, 2021 | ||
| Boavista | 1 - 0 | Moreirense |
| February 17, 2021 | ||
| Vitoria Guimaraes | 2 - 2 | Farense |
| February 16, 2021 | ||
| Tondela | 2 - 1 | Marítimo |
