| October 22, 2021 | ||
| Vitoria Guimaraes | 21:15 | Marítimo |
| October 23, 2021 | ||
| Santa Clara | 16:30 | Famalicão |
| Tondela | 19:00 | Porto |
| Sporting Lisbon | 21:30 | Moreirense |
| October 24, 2021 | ||
| Paços Ferreira | 16:30 | Arouca |
| Vizela | 19:00 | Benfica |
| Portimonense | 21:30 | Estoril |
| October 25, 2021 | ||
| Gil Vicente | 20:00 | SC Braga |
| Boavista | 22:15 | Belenenses |
| October 29, 2021 | ||
| Arouca | 21:15 | Tondela |
| October 30, 2021 | ||
| Porto | 18:00 | Boavista |
| Estoril | 20:00 | Benfica |
| Sporting Lisbon | 22:15 | Vitoria Guimaraes |
| October 31, 2021 | ||
| Marítimo | 18:30 | Gil Vicente |
| Belenenses | 21:00 | Santa Clara |
| Famalicão | 23:30 | Vizela |
| November 1, 2021 | ||
| SC Braga | 22:00 | Portimonense |
| November 2, 2021 | ||
| Moreirense | 00:15 | Paços Ferreira |
| November 5, 2021 | ||
| Gil Vicente | 22:00 | Arouca |
| November 6, 2021 | ||
| Boavista | 00:15 | Famalicão |
