| October 7, 2022 | ||
| Gil Vicente | 21:15 | Estoril |
| October 8, 2022 | ||
| Santa Clara | 16:30 | Sporting Lisbon |
| Portimonense | 19:00 | Porto |
| Benfica | 19:00 | Rio Ave |
| Paços Ferreira | 21:30 | Vitoria Guimaraes |
| October 9, 2022 | ||
| Boavista | 16:30 | Marítimo |
| Casa Pia | 19:00 | Vizela |
| SC Braga | 21:30 | Chaves |
| October 10, 2022 | ||
| Arouca | 21:15 | Famalicão |
| October 21, 2022 | ||
| Porto | 21:15 | Benfica |
| October 22, 2022 | ||
| Famalicão | 16:30 | Paços Ferreira |
| Estoril | 19:00 | SC Braga |
| Sporting Lisbon | 21:30 | Casa Pia |
| October 23, 2022 | ||
| Vizela | 16:30 | Santa Clara |
| Marítimo | 16:30 | Arouca |
| Chaves | 19:00 | Gil Vicente |
| Vitoria Guimaraes | 21:30 | Boavista |
| October 24, 2022 | ||
| Rio Ave | 21:15 | Portimonense |
| October 28, 2022 | ||
| Paços Ferreira | 21:15 | Marítimo |
