| August 6, 2021 | ||
| Sporting Lisbon | 21:15 | Vizela |
| August 7, 2021 | ||
| Arouca | 13:45 | Estoril |
| Moreirense | 19:00 | Benfica |
| Marítimo | 21:30 | SC Braga |
| August 8, 2021 | ||
| Vitoria Guimaraes | 16:30 | Portimonense |
| Tondela | 16:30 | Santa Clara |
| Porto | 19:00 | Belenenses |
| Paços Ferreira | 21:30 | Famalicão |
| August 9, 2021 | ||
| Gil Vicente | 21:15 | Boavista |
| August 14, 2021 | ||
| Boavista | 02:00 | Paços Ferreira |
| Vizela | 02:00 | Tondela |
| Estoril | 02:00 | Vitoria Guimaraes |
| Portimonense | 02:00 | Gil Vicente |
| Santa Clara | 02:00 | Moreirense |
| Belenenses | 02:00 | Marítimo |
| Famalicão | 02:00 | Porto |
| SC Braga | 02:00 | Sporting Lisbon |
| Benfica | 02:00 | Arouca |
