| January 30, 2022 | ||
| Vizela | 17:30 | Vitoria Guimaraes |
| Portimonense | 17:30 | Tondela |
| SC Braga | 20:00 | Moreirense |
| Porto | 22:30 | Marítimo |
| January 31, 2022 | ||
| Estoril | 21:00 | Paços Ferreira |
| Famalicão | 23:15 | Arouca |
| February 1, 2022 | ||
| Santa Clara | 22:15 | Boavista |
| February 2, 2022 | ||
| Benfica | 21:00 | Gil Vicente |
| Belenenses | 22:45 | Sporting Lisbon |
| February 5, 2022 | ||
| Marítimo | 17:30 | Estoril |
| Paços Ferreira | 20:00 | Portimonense |
| Vitoria Guimaraes | 22:30 | SC Braga |
| February 6, 2022 | ||
| Gil Vicente | 17:30 | Santa Clara |
| Boavista | 17:30 | Vizela |
| Arouca | 20:00 | Porto |
| Sporting Lisbon | 22:30 | Famalicão |
| February 7, 2022 | ||
| Tondela | 21:00 | Benfica |
| Moreirense | 23:15 | Belenenses |
| February 11, 2022 | ||
| Porto | 22:15 | Sporting Lisbon |
