| March 8, 2021 | ||
| Belenenses | 22:15 | Benfica |
| March 9, 2021 | ||
| SC Braga | 23:45 | Vitoria Guimaraes |
| March 12, 2021 | ||
| Nacional | 22:30 | Marítimo |
| March 13, 2021 | ||
| Farense | 17:30 | Belenenses |
| Benfica | 20:00 | Boavista |
| Santa Clara | 20:00 | Portimonense |
| Tondela | 22:30 | Sporting CP |
| March 14, 2021 | ||
| Moreirense | 17:00 | Rio Ave |
| Vitoria Guimaraes | 19:30 | Gil Vicente |
| Porto | 22:00 | Paços de Ferreira |
| March 15, 2021 | ||
| Famalicão | 22:15 | SC Braga |
| March 19, 2021 | ||
| Gil Vicente | 22:30 | Nacional |
| March 20, 2021 | ||
| Paços de Ferreira | 17:30 | Moreirense |
| Santa Clara | 17:30 | Tondela |
| Portimonense | 20:00 | Porto |
| Sporting CP | 22:30 | Vitoria Guimaraes |
| March 21, 2021 | ||
| Rio Ave | 17:00 | Belenenses |
| Marítimo | 19:30 | Famalicão |
| Boavista | 19:30 | Farense |
| SC Braga | 22:00 | Benfica |
