| November 27, 2020 | ||
| Paços de Ferreira | 21:00 | Famalicão |
| Tondela | 23:00 | Vitoria Guimaraes |
| November 28, 2020 | ||
| Santa Clara | 20:00 | Porto |
| Sporting CP | 22:30 | Moreirense |
| November 29, 2020 | ||
| Gil Vicente | 17:00 | Rio Ave |
| Portimonense | 17:00 | Nacional |
| Boavista | 19:30 | Belenenses |
| SC Braga | 22:00 | Farense |
| November 30, 2020 | ||
| Marítimo | 21:00 | Benfica |
| December 1, 2020 | ||
| Moreirense | 23:45 | Paços de Ferreira |
| December 5, 2020 | ||
| Vitoria Guimaraes | 17:30 | Portimonense |
| Moreirense | 17:30 | Gil Vicente |
| Famalicão | 20:00 | Sporting CP |
| Porto | 22:30 | Tondela |
| December 6, 2020 | ||
| Nacional | 17:00 | Santa Clara |
| Rio Ave | 19:30 | Boavista |
| Benfica | 22:00 | Paços de Ferreira |
| Belenenses | 22:00 | SC Braga |
| December 7, 2020 | ||
| Farense | 22:15 | Marítimo |
