| October 16, 2021 | ||
| Hibernian | 16:00 | Dundee United |
| Rangers | 16:00 | Hearts |
| Ross County | 16:00 | St. Mirren |
| St. Johnstone | 16:00 | Livingston |
| Motherwell | 16:00 | Celtic |
| Dundee | 19:00 | Aberdeen |
| October 23, 2021 | ||
| Hearts | 16:00 | Dundee |
| Ross County | 16:00 | Livingston |
| Dundee United | 16:00 | Motherwell |
| Celtic | 16:00 | St. Johnstone |
| Aberdeen | 16:00 | Hibernian |
| October 24, 2021 | ||
| St. Mirren | 13:00 | Rangers |
| October 27, 2021 | ||
| Dundee | 20:45 | Ross County |
| Hibernian | 20:45 | Celtic |
| Livingston | 20:45 | Dundee United |
| Motherwell | 20:45 | St. Mirren |
| Rangers | 20:45 | Aberdeen |
| St. Johnstone | 20:45 | Hearts |
