| October 4, 2022 | ||
| Ross County | 20:45 | Motherwell |
| October 5, 2022 | ||
| Kilmarnock | 20:45 | St. Johnstone |
| October 8, 2022 | ||
| St. Johnstone | 13:30 | Celtic |
| Hibernian | 16:00 | Motherwell |
| Livingston | 16:00 | Ross County |
| Rangers | 16:00 | St. Mirren |
| Dundee United | 19:00 | Aberdeen |
| October 9, 2022 | ||
| Kilmarnock | 16:00 | Hearts |
| October 11, 2022 | ||
| Dundee United | 20:45 | Hibernian |
| October 15, 2022 | ||
| Livingston | 16:00 | St. Johnstone |
| Ross County | 16:00 | Dundee United |
| St. Mirren | 16:00 | Kilmarnock |
| Celtic | 16:00 | Hibernian |
| October 16, 2022 | ||
| Motherwell | 13:00 | Rangers |
| Aberdeen | 16:00 | Hearts |
| October 21, 2022 | ||
| Hibernian | 20:30 | St. Johnstone |
