| October 2, 2022 | ||
| Espanyol | 2 - 2 | Valencia |
| October 1, 2022 | ||
| Mallorca | 0 - 1 | Barcelona |
| Sevilla | 0 - 2 | Atlético de Madrid |
| Getafe | 2 - 3 | Real Valladolid |
| Cadiz | 0 - 0 | Villarreal |
| September 30, 2022 | ||
| Athletic Bilbao | 4 - 0 | Almeria |
| September 18, 2022 | ||
| Atlético de Madrid | 1 - 2 | Real Madrid |
| Real Sociedad | 2 - 1 | Espanyol |
| Real Betis | 2 - 1 | Girona |
| Villarreal | 1 - 1 | Sevilla |
| Osasuna | 0 - 2 | Getafe |
| September 17, 2022 | ||
| Athletic Bilbao | 3 - 2 | Rayo Vallecano |
| Valencia | 3 - 0 | Celta Vigo |
| Barcelona | 3 - 0 | Elche |
| Mallorca | 1 - 0 | Almeria |
| September 16, 2022 | ||
| Real Valladolid | 0 - 1 | Cadiz |
| September 12, 2022 | ||
| Almeria | 0 - 1 | Osasuna |
