| January 23, 2022 | ||
| Alaves | 0 - 1 | Barcelona |
| Rayo Vallecano | 0 - 1 | Athletic Bilbao |
| Real Sociedad | 0 - 0 | Getafe |
| Real Madrid | 2 - 2 | Elche |
| Granada | 0 - 2 | Osasuna |
| January 22, 2022 | ||
| Atlético de Madrid | 3 - 2 | Valencia |
| Sevilla | 2 - 2 | Celta Vigo |
| Villarreal | 3 - 0 | Mallorca |
| Levante | 0 - 2 | Cadiz |
| January 21, 2022 | ||
| Espanyol | 1 - 4 | Real Betis |
| January 20, 2022 | ||
| Getafe | 4 - 2 | Granada |
| January 19, 2022 | ||
| Valencia | 1 - 1 | Sevilla |
| Celta Vigo | 2 - 0 | Osasuna |
| January 18, 2022 | ||
| Cadiz | 2 - 2 | Espanyol |
| Real Betis | 4 - 0 | Alaves |
| January 16, 2022 | ||
| Elche | 1 - 0 | Villarreal |
| January 10, 2022 | ||
| Espanyol | 1 - 2 | Elche |
