| October 3, 2021 | ||
| Granada | 1 - 0 | Sevilla |
| Villarreal | 2 - 0 | Real Betis |
| Getafe | 1 - 1 | Real Sociedad |
| Espanyol | 2 - 1 | Real Madrid |
| Elche | 1 - 0 | Celta Vigo |
| October 2, 2021 | ||
| Atlético de Madrid | 2 - 0 | Barcelona |
| Cadiz | 0 - 0 | Valencia |
| Mallorca | 1 - 0 | Levante |
| Osasuna | 1 - 0 | Rayo Vallecano |
| October 1, 2021 | ||
| Athletic Bilbao | 1 - 0 | Alaves |
| September 27, 2021 | ||
| Celta Vigo | 1 - 0 | Granada |
| September 26, 2021 | ||
| Real Betis | 2 - 0 | Getafe |
| Rayo Vallecano | 3 - 1 | Cadiz |
| Real Sociedad | 1 - 0 | Elche |
| Barcelona | 3 - 0 | Levante |
| Mallorca | 2 - 3 | Osasuna |
| September 25, 2021 | ||
| Real Madrid | 0 - 0 | Villarreal |
| Sevilla | 2 - 0 | Espanyol |
| Valencia | 1 - 1 | Athletic Bilbao |
| Alaves | 1 - 0 | Atlético de Madrid |
