| August 13, 2021 | ||
| Brentford | 21:00 | Arsenal |
| August 14, 2021 | ||
| Manchester United | 13:30 | Leeds United |
| Burnley | 16:00 | Brighton & Hov… |
| Chelsea | 16:00 | Crystal Palace |
| Everton | 16:00 | Southampton |
| Leicester City | 16:00 | Wolverhampton Wanderers |
| Watford | 16:00 | Aston Villa |
| Norwich City | 18:30 | Liverpool |
| August 15, 2021 | ||
| Newcastle United | 15:00 | West Ham United |
| Tottenham Hotspur | 17:30 | Manchester City |
| August 21, 2021 | ||
| Liverpool | 13:30 | Burnley |
| Manchester City | 16:00 | Norwich City |
| Wolverhampton Wanderers | 16:00 | Tottenham Hotspur |
| Aston Villa | 16:00 | Newcastle United |
| Leeds United | 16:00 | Everton |
| Crystal Palace | 16:00 | Brentford |
| Brighton & Hov… | 18:30 | Watford |
| August 22, 2021 | ||
| Southampton | 15:00 | Manchester United |
| Arsenal | 17:30 | Chelsea |
| August 23, 2021 | ||
| West Ham United | 21:00 | Leicester City |
