| September 10, 2022 | ||
| AFC Bournemouth | 02:00 | Brighton & Hov… |
| Leicester City | 02:00 | Aston Villa |
| Liverpool | 02:00 | Wolverhampton Wanderers |
| Manchester City | 02:00 | Tottenham Hotspur |
| Southampton | 02:00 | Brentford |
| Fulham | 02:00 | Chelsea |
| September 11, 2022 | ||
| Arsenal | 02:00 | Everton |
| Crystal Palace | 02:00 | Manchester United |
| West Ham United | 02:00 | Newcastle United |
| September 12, 2022 | ||
| Leeds United | 02:00 | Nottingham Forest |
| September 17, 2022 | ||
| Brighton & Hov… | 02:00 | Crystal Palace |
| September 18, 2022 | ||
| Chelsea | 02:00 | Liverpool |
| Manchester United | 02:00 | Leeds United |
| October 2, 2022 | ||
| Leeds United | 17:30 | Aston Villa |
| October 3, 2022 | ||
| Leicester City | 21:00 | Nottingham Forest |
| October 8, 2022 | ||
| Manchester City | 16:00 | Southampton |
| Newcastle United | 16:00 | Brentford |
| Chelsea | 16:00 | Wolverhampton Wanderers |
| AFC Bournemouth | 16:00 | Leicester City |
| Brighton & Hov… | 18:30 | Tottenham Hotspur |
