| January 17, 2021 | ||
| Aston Villa | 02:00 | Everton |
| March 8, 2021 | ||
| Chelsea | 20:00 | Everton |
| West Ham United | 22:00 | Leeds United |
| March 10, 2021 | ||
| Manchester City | 20:00 | Southampton |
| March 12, 2021 | ||
| Newcastle United | 22:00 | Aston Villa |
| March 13, 2021 | ||
| Leeds United | 14:30 | Chelsea |
| Crystal Palace | 17:00 | West Bromwich Albion |
| Everton | 19:30 | Burnley |
| Fulham | 22:00 | Manchester City |
| March 14, 2021 | ||
| Southampton | 14:00 | Brighton & Hov… |
| Leicester City | 16:00 | Sheffield United |
| Arsenal | 18:30 | Tottenham Hotspur |
| Manchester United | 21:15 | West Ham United |
| March 15, 2021 | ||
| Wolverhampton Wanderers | 22:00 | Liverpool |
| March 19, 2021 | ||
| Fulham | 22:00 | Leeds United |
| March 20, 2021 | ||
| Tottenham Hotspur | 02:00 | Southampton |
| Brighton & Hov… | 22:00 | Newcastle United |
| March 21, 2021 | ||
| West Ham United | 17:00 | Arsenal |
| Aston Villa | 21:30 | Tottenham Hotspur |
