| September 25, 2021 | ||
| Chelsea | 13:30 | Manchester City |
| Manchester United | 13:30 | Aston Villa |
| Everton | 16:00 | Norwich City |
| Leeds United | 16:00 | West Ham United |
| Leicester City | 16:00 | Burnley |
| Watford | 16:00 | Newcastle United |
| Brentford | 18:30 | Liverpool |
| September 26, 2021 | ||
| Southampton | 15:00 | Wolverhampton Wanderers |
| Arsenal | 17:30 | Tottenham Hotspur |
| September 27, 2021 | ||
| Crystal Palace | 21:00 | Brighton & Hov… |
| October 2, 2021 | ||
| Manchester United | 13:30 | Everton |
| Wolverhampton Wanderers | 16:00 | Newcastle United |
| Burnley | 16:00 | Norwich City |
| Leeds United | 16:00 | Watford |
| Chelsea | 16:00 | Southampton |
| Brighton & Hov… | 18:30 | Arsenal |
| October 3, 2021 | ||
| Crystal Palace | 15:00 | Leicester City |
| Tottenham Hotspur | 15:00 | Aston Villa |
| West Ham United | 15:00 | Brentford |
| Liverpool | 17:30 | Manchester City |
