| September 12, 2020 | ||
| Burnley | 02:00 | Manchester United |
| Manchester City | 02:00 | Aston Villa |
| September 26, 2020 | ||
| Brighton & Hov… | 13:30 | Manchester United |
| Crystal Palace | 16:00 | Everton |
| West Bromwich Albion | 18:30 | Chelsea |
| Burnley | 21:00 | Southampton |
| September 27, 2020 | ||
| Sheffield United | 13:00 | Leeds United |
| Tottenham Hotspur | 15:00 | Newcastle United |
| Manchester City | 17:30 | Leicester City |
| West Ham United | 20:00 | Wolverhampton Wanderers |
| September 28, 2020 | ||
| Fulham | 18:45 | Aston Villa |
| Liverpool | 21:00 | Arsenal |
| October 3, 2020 | ||
| Chelsea | 13:30 | Crystal Palace |
| Everton | 16:00 | Brighton & Hov… |
| Leeds United | 18:30 | Manchester City |
| Newcastle United | 21:00 | Burnley |
