| November 28, 2021 | ||
| Burnley | 02:00 | Tottenham Hotspur |
| December 12, 2021 | ||
| Brighton & Hov… | 02:00 | Tottenham Hotspur |
| December 18, 2021 | ||
| Aston Villa | 02:00 | Burnley |
| Manchester United | 02:00 | Brighton & Hov… |
| Watford | 02:00 | Crystal Palace |
| December 26, 2021 | ||
| Burnley | 02:00 | Everton |
| Liverpool | 02:00 | Leeds United |
| Wolverhampton Wanderers | 02:00 | Watford |
| December 28, 2021 | ||
| Leeds United | 02:00 | Aston Villa |
| Arsenal | 02:00 | Wolverhampton Wanderers |
| December 30, 2021 | ||
| Everton | 02:00 | Newcastle United |
| January 1, 2022 | ||
| Leicester City | 02:00 | Norwich City |
| January 2, 2022 | ||
| Southampton | 02:00 | Newcastle United |
| January 11, 2022 | ||
| Everton | 02:00 | Leicester City |
| January 15, 2022 | ||
| Burnley | 02:00 | Leicester City |
| January 16, 2022 | ||
| Tottenham Hotspur | 02:00 | Arsenal |
| February 5, 2022 | ||
| Burnley | 20:00 | Watford |
| February 8, 2022 | ||
| West Ham United | 21:45 | Watford |
| Newcastle United | 21:45 | Everton |
| Burnley | 22:00 | Manchester United |
