| October 3, 2021 | ||
| Liverpool | 2 - 2 | Manchester City |
| West Ham United | 1 - 2 | Brentford |
| Tottenham Hotspur | 2 - 1 | Aston Villa |
| Crystal Palace | 2 - 2 | Leicester City |
| October 2, 2021 | ||
| Brighton & Hov… | 0 - 0 | Arsenal |
| Wolverhampton Wanderers | 2 - 1 | Newcastle United |
| Leeds United | 1 - 0 | Watford |
| Chelsea | 3 - 1 | Southampton |
| Burnley | 0 - 0 | Norwich City |
| Manchester United | 1 - 1 | Everton |
| September 27, 2021 | ||
| Crystal Palace | 1 - 1 | Brighton & Hov… |
| September 26, 2021 | ||
| Arsenal | 3 - 1 | Tottenham Hotspur |
| Southampton | 0 - 1 | Wolverhampton Wanderers |
| September 25, 2021 | ||
| Brentford | 3 - 3 | Liverpool |
| Everton | 2 - 0 | Norwich City |
| Leeds United | 1 - 2 | West Ham United |
| Leicester City | 2 - 2 | Burnley |
| Watford | 1 - 1 | Newcastle United |
| Manchester United | 0 - 1 | Aston Villa |
| Chelsea | 0 - 1 | Manchester City |
