| January 23, 2022 | ||
| Chelsea | 2 - 0 | Tottenham Hotspur |
| Leicester City | 1 - 1 | Brighton & Hov… |
| Crystal Palace | 1 - 3 | Liverpool |
| Arsenal | 0 - 0 | Burnley |
| January 22, 2022 | ||
| Southampton | 1 - 1 | Manchester City |
| Manchester United | 1 - 0 | West Ham United |
| Leeds United | 0 - 1 | Newcastle United |
| Brentford | 1 - 2 | Wolverhampton Wanderers |
| Everton | 0 - 1 | Aston Villa |
| January 21, 2022 | ||
| Watford | 0 - 3 | Norwich City |
| January 19, 2022 | ||
| Brentford | 1 - 3 | Manchester United |
| Leicester City | 2 - 3 | Tottenham Hotspur |
| January 18, 2022 | ||
| Brighton & Hov… | 1 - 1 | Chelsea |
| January 16, 2022 | ||
| West Ham United | 2 - 3 | Leeds United |
| Liverpool | 3 - 0 | Brentford |
| January 15, 2022 | ||
| Aston Villa | 2 - 2 | Manchester United |
| Wolverhampton Wanderers | 3 - 1 | Southampton |
| Norwich City | 2 - 1 | Everton |
| Newcastle United | 1 - 1 | Watford |
| Manchester City | 1 - 0 | Chelsea |
