| September 21, 2020 | ||
| Wolverhampton Wanderers | 1 - 3 | Manchester City |
| Aston Villa | 1 - 0 | Sheffield United |
| September 20, 2020 | ||
| Leicester City | 4 - 2 | Burnley |
| Chelsea | 0 - 2 | Liverpool |
| Newcastle United | 0 - 3 | Brighton & Hov… |
| Southampton | 2 - 5 | Tottenham Hotspur |
| September 19, 2020 | ||
| Arsenal | 2 - 1 | West Ham United |
| Manchester United | 1 - 3 | Crystal Palace |
| Leeds United | 4 - 3 | Fulham |
| Everton | 5 - 2 | West Bromwich Albion |
| September 14, 2020 | ||
| Brighton & Hov… | 1 - 3 | Chelsea |
| Sheffield United | 0 - 2 | Wolverhampton Wanderers |
| September 13, 2020 | ||
| Tottenham Hotspur | 0 - 1 | Everton |
| West Bromwich Albion | 0 - 3 | Leicester City |
| September 12, 2020 | ||
| West Ham United | 0 - 2 | Newcastle United |
| Liverpool | 4 - 3 | Leeds United |
| Crystal Palace | 1 - 0 | Southampton |
| Fulham | 0 - 3 | Arsenal |
